En mi experiencia con el de AES (el último que salio) hay algún bug en algún juego, pero son cosas muy excepcionales. La Mayoría van perfectamente, y el sonido perfecto. He comparado con los originales.
También hay que tener en cuenta que hay varias versiones hasta 4, y fueron añadiendo condensadores y puentes.
https://wiki.neogeodev.org/index.php?title=161-in-1_Series_1El peor bug es el crash en motw muy fácil de forzar. A la siguiente lista hay que añadir el samurai I o II no recuerdo cual era tenía fallos en sprites.
Known Game Issues (Version 1 / Version 2)Aero Fighters 2 - Will not play correctly unless in Japanese region (button check code inserted into ROM over game data).
Magical Drop II - Hiscore table is broken when drawn to screen (the start button trigger timer var stored at 0x10FF20, a region used by the game and MESS_OUT). This issue may affect other games also.
Magical Drop III - Hiscore table is broken when drawn to screen (the start button trigger timer var stored at 0x10FF20, a region used by the game and MESS_OUT). This issue may affect other games also.
Blue's Journey - Game will not have sound until system soft reset (probably due to corrupted Z80 ROM image).
Puzzle Bobble 2 - Can causes crash when selected from the game list. Looks dependant on MVS type (happens on my MV-1FS but not MV-1FT). The game works correctly once a soft reset is done after the crash.
Alpha Mission II - Game name displayed in the testmode softdip settings screen is byte flipped (stored incorrectly in the carts game name tables).
Metal Slug 3 - Has NGH of 0x299 (mslug6 hack). When in USA region the 'parental advisory warning' screen is corrupted. When set to Japanese language (softDIP) the Japanese how to play font is corrupted.
Garou MOTW - Will crash when preforming Kim's B+C top attack, this due to 161-in-1 using the prototype version of the game.
There are probably other game issues also.