Vanquish will have four difficulty modes when it ships this October. Director Shinji Mikami revealed them all on the Platinum Games blog today, specifically boasting Casual Automatic.
Casual Automatic mode is an “easy as pie” difficulty that will auto aim onto enemies rather than have you aim yourself. Mikami says while it does make the game sound “uninteresting”, it’s tempo will make you jump up and say, “woohoo!”
The other three game modes are simply Casual, Normal, and Hard. Mikami recommends you play on normal difficulty, even though “it takes some time to get used to aiming and firing enemies on your own”.